Letrozole is a molecule found in the medications FERAMA or LETROMINA.
It is used in adjuvant early-stage breast cancer treatments with positive hormone receptors in menopausal women.
But it is also prescribed if adjuvant early-stage breast cancer is prolonged in menopausal women who have already followed a standard tamoxifen treatment for 5 years, or even in first-line hormone-dependent advanced-stage breast cancer.
People also take it to treat advanced-stage breast cancer in menopausal women (natural or artificial menopause) after a relapse or if the disease progresses in women after treatment from gentler antiestrogens.
The recommended prescribed dose of Letrozole is 2.5 milligrams daily. The dose does not need to be adjusted for elderly patients.
How Does Letrozole Act?
Like a number of medications that treat this type of cancer, this molecule acts directly to stop estrogen stimulation.
However this product was diverted for two reasons, first to fight infertility and then by a certain type of athletes.
In terms of treating fertility, doctors discovered that it stimulated ovulation, and began prescribing Letrozole to women experiencing fertility problems who wanted to have children. Yet this is by no means the primary purpose of this product, though many women have taken this treatment with success.
Why does a drug meant to treat breast cancer in menopausal women interest athletes, and what athletes want to take this product?
Athletes who take testosterone, often accompanied by other steroids, aim to quickly gain substantial muscle mass; in this case, dry muscle mass gains. This indicates that users are bodybuilders or athletes requiring high explosiveness.
Yet taking these kinds of products comes with numerous disadvantages, so you should not take testosterone without combining it with a supplementary treatment.
Letrozole’s Side Effects
What constraints can these people encounter?
Athletes using these products must be very vigilant concerning a large number of side effects. There is significant risk of muscle tears, and tendonitis is also very common.
It’s also possible to confront skin problems with acne development. Virilization risks exist for men as well as women, not to mention impotence, headaches, liver troubles, and breast development in men, called gynecomastia.
These problems are caused by the aromatization of the anabolic steroid. Testosterone then converts to estrogen and attaches to the mammary glands, which causes breasts to develop in men. The first symptoms of gynecomastia are tenderness, hypersensitivity and finally swelling in the breasts.
To avoid this issue, you must take a product that directly stops estrogen stimulation. Letrozole is one such molecule that corresponds perfectly to these kinds of symptoms and helps prevent the situation. In fact, it has been proven that Letrozole reduces the level of estrogen in the body by 98% or more.
Whether for bodybuilders or athletes, it is used as an anabolic compound in steroid cycles because, as we have indicated above, it substantially reduces the amount of estrogen in the body. Additionally, it slightly increases testosterone.
Letrozole, besides reducing the percentage of estrogen (lowering them to virtually zero) makes it possible to develop this mass during bulking phases in addition to eliminating water and improving muscle definition.
Furthermore, Letrozole limits side effects in bodybuilders who regularly do steroid treatments and suffer testicular reduction related to taking other products. But also – which is no small thing – it limits or reduces gynecomastia that is beginning or already present.
However Letrozole has genuine adverse effects. The most commonly observed are abundant perspiration, bone/joint pain, heavy fatigue and hot flashes.
Bodybuilders on the other hand have completely different reasons for finding this product appropriate. For them, less estrogen in the body means less chance of encountering side effects like water retention, gynecomastia or acne compared to other products.
Letrozole is two to five times more powerful than anastrozole (Arimidex), but its effects are slower to start. You must take Letrozole for 60 days to obtain a good balance in the blood plasma. For shorter durations, results will be less visible or non-existant.
Finally, for experienced weightlifters or better yet competitive bodybuilders, this product brings good results even while they take products that make them significantly “gain” mass. Not to mention that it successfully avoids water retention and therefore striates the muscles and improves definition. Meanwhile, it guarantees to “halt” the negative affects of the other products that users take. Therefore it is truly advantageous for bodybuilders to take this product.